Chemical Structure : WXSH0208
CAS No.:
2741952-21-4
WXSH0208
Catalog No.: PC-27363Not For Human Use, Lab Use Only.
WXSH0208 is a baloxavir marboxil derivative and selective inhibitor of influenza RNA polymerase subunit, inhibits cap-dependent endonuclease (CEN), shows antiviral activity against influenza A and B viruses in vitro, including strains resistant to baloxavir, also inhibits Crimean-Congo haemorrhagic fever virus (CCHFV) endonuclease activity and suppresses viral replication with EC50 of 4.2 uM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
WXSH0208 is a baloxavir marboxil derivative and selective inhibitor of influenza RNA polymerase subunit, inhibits cap-dependent endonuclease (CEN), shows antiviral activity against influenza A and B viruses in vitro, including strains resistant to baloxavir, also inhibits Crimean-Congo haemorrhagic fever virus (CCHFV) endonuclease activity and suppresses viral replication with EC50 of 4.2 uM.
Physicochemical Properties
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M.Wt
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439.42
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Formula
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C23H19F2N3O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(7aS,16R)-2,3-difluoro-10-hydroxy-8-methyl-16-phenyl-6,7,7a,8-tetrahydro-16H-benzo[b]pyrido[1',2':1,6][1,2,4]triazino[2,3-e][1,5]oxazocine-9,11-dione
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References
1. Feng, J. et al. J. Med. Chem. 67, 2570–2583 (2024).
2. Cao W, et al. J Infect Dis. 2025 Aug 14;232(2):441-449.
3. Xue L, et al. Nature. 2026 Jul 22. doi: 10.1038/s41586-026-10701-6.
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