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Chemical Structure : WY-135
Catalog No.: PC-35262Not For Human Use, Lab Use Only.
WY-135 (WY135) is a potent inhibitor of ALK and ROS1 with IC50 of 1.2 and 0.48 nM, respectively.
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WY-135 (WY135) is a potent inhibitor of ALK and ROS1 with IC50 of 1.2 and 0.48 nM, respectively.
WY-135 exhibits better enzyme inhibitory activity than ceritinib, demonstrates anti-proliferative effects on Karpas299 and H2228 cells with IC50 of 28 and 164 nM respectively in MTT assay.
WY-135 induces cell cycle arrest at G1 phase in a dose-dependent manner and subsequently progressed into apoptosis, significantly suppressed ALK and its downstream protein expression.
| M.Wt | 612.15 | |
| Formula | C28H34ClN9O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Han M, et al. Chem Biol Interact. 2018 Mar 25;284:24-31.
2. Wang Y, et al. Eur J Med Chem. 2018 Jan 1;143:123-136.
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