WY-135 | ALK/ROS1 inhibitor | Probechem Biochemicals

Chemical Structure : WY-135

WY-135 (WY135)

Catalog No.: PC-35262Not For Human Use, Lab Use Only.

WY-135 (WY135) is a potent inhibitor of ALK and ROS1 with IC50 of 1.2 and 0.48 nM, respectively.

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Biological Activity

WY-135 (WY135) is a potent inhibitor of ALK and ROS1 with IC50 of 1.2 and 0.48 nM, respectively.
WY-135 exhibits better enzyme inhibitory activity than ceritinib, demonstrates anti-proliferative effects on Karpas299 and H2228 cells with IC50 of 28 and 164 nM respectively in MTT assay.
WY-135 induces cell cycle arrest at G1 phase in a dose-dependent manner and subsequently progressed into apoptosis, significantly suppressed ALK and its downstream protein expression.

Physicochemical Properties

M.Wt	612.15
Formula	C28H34ClN9O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-chloro-N4-(2-(isopropylsulfonyl)phenyl)-N2-(2-methoxy-4-(4-((4-methylpiperazin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)phenyl)pyrimidine-2,4-diamine

References

1. Han M, et al. Chem Biol Interact. 2018 Mar 25;284:24-31.

2. Wang Y, et al. Eur J Med Chem. 2018 Jan 1;143:123-136.

WY-135 (WY135)

Biological Activity

Physicochemical Properties

References

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