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Chemical Structure : WZ-2-033
Catalog No.: PC-21874Not For Human Use, Lab Use Only.
WZ-2-033 is a potent, selective STAT3 inhibitor, binds to the SH2 domain of the STAT3 protein with KD of 7.4 uM, disrupts STAT3 dimerization and significantly inhibits STAT3 signaling.
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WZ-2-033 is a potent, selective STAT3 inhibitor, binds to the SH2 domain of the STAT3 protein with KD of 7.4 uM, disrupts STAT3 dimerization and significantly inhibits STAT3 signaling.
WZ-2-033 preferentially suppresses STAT3-DNA binding, with no obvious effect on STAT5-DNA-binding activity.
WZ-2-033 suppresses STAT3-dependent transcriptional activation, reduces tyrosine (Y705) phosphorylation level of STAT3 in HEK-293T cells, inhibits the expression of STAT3 downstream genes, including Bcl-2, Bcl-xL, and c-Myc, in TNBC and GC cells.
WZ-2-033 strongly suppresses the proliferation, colony survival, migration, and invasion of TNBC and GC cells with aberrantly active STAT3.
WZ-2-033 (5 or 15 mg/kg, i.p. per day) inhibits tumor growth in MGC-803 xenograft mice, significantly suppresses the level of pY705-STAT3 and subsequently downregulated the expression of STAT3-targeted genes in human TNBC cell xenografts.
| M.Wt | 513.49 | |
| Formula | C25H18F3N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yan Zhong, et al. Acta Pharmacol Sin. 2022 Apr;43(4):1013-1023.
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