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Chemical Structure : WZ-4-49-8
Catalog No.: PC-61638Not For Human Use, Lab Use Only.
WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM.
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WZ-4-49-8 is a potent, selective c-Fes protein-tyrosine kinase inhibitor with IC50 of 67 nM.
WZ-4-49-8 displays an exceptional selectivity profile with a selectivity score of only 0.027 in a panel of 442 kinases.
WZ-4-49-8 inhibits c-Fes-L145P autophosphorylation and microtubule association in at least a subset of cells, and potently inhibits c-Fes-L145P-mediated soft-agar colony growth.
WZ-4-49-8 dramatically inhibits osteoclast differentiation in RAW 264.7 macrophage cell line.
| M.Wt | 618.801 | |
| Formula | C32H42N8O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hellwig S, et al. Chem Biol. 2012 Apr 20;19(4):529-40.
2. Weir MC, et al. PLoS One. 2017 Jul 20;12(7):e0181178.
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