WZH-15-125

Chemical Structure : WZH-15-125

Catalog No.: PC-24806Not For Human Use, Lab Use Only.

WZH-15-125 is a potent, selective ALK inhibitor with actiivty against Ba/F3 cells expressing ALK mutations (ALK WT, IC50<1.6 nM; ALK L1196 M, IC50=16.2 nM), overcomes resistance to all generations of ALK TKIs.

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Biological Activity

Physicochemical Properties

M.Wt	745.74
Formula	C33H45BrN8O5S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-((5-bromo-2-((5-ethyl-2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)-N-methylmethanesulfonamide

References

1. Gao F, et al. Eur J Med Chem. 2025 Jun 2;296:117835.

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WZH-15-125

Biological Activity

Physicochemical Properties

References

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