Wee1 Inhibitor II

Chemical Structure : Wee1 Inhibitor II

Catalog No.: PC-72319Not For Human Use, Lab Use Only.

Wee1 Inhibitor II is a potent, selective, ATP-binding site-targeting inhibitor of Wee1 with IC50 of 59 nM, 590-fold selectivity over the related checkpoint kinase Chk1 (IC50=35 uM).

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Biological Activity

Wee1 Inhibitor II is a potent, selective, ATP-binding site-targeting inhibitor of Wee1 with IC50 of 59 nM, 590-fold selectivity over the related checkpoint kinase Chk1 (IC50=35 uM).

Physicochemical Properties

M.Wt	418.877
Formula	C24H19ClN2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility
Chemical Name/SMILES	6-Butyl-4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3-(2H,6H)-dione

References

1. Palmer, B.D., et al. 2006. J. Med. Chem. 49: 4896-4911.

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