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Wntepane 1

Chemical Structure : Wntepane 1

CAS No.: 1314885-81-8

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Wntepane 1

Catalog No.: PC-62039Not For Human Use, Lab Use Only.

Wntepane 1 is a small-molecule activator of the Wnt pathway that modulates the van-Gogh-like receptor 1 (Vangl1), activates Wnt signaling with EC50 of 1.8 uM in the reporter gene assay.

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    Biological Activity

    Wntepane 1 is a small-molecule activator of the Wnt pathway that modulates the van-Gogh-like receptor 1 (Vangl1), activates Wnt signaling with EC50 of 1.8 uM in the reporter gene assay.
    Wntepane 1 interacts with Vangl1 (and possibly Vangl2 as well) and thereby at least partially liberates and restores the signal transducing activity of Dsh.
    Wntepane 1 is an advantageous tool for the study of biological processes mediated by Vangl1.

    Physicochemical Properties

    M.Wt 474.557
    Formula C28H30N2O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3aR,9R,10aR,10bS)-6,6-dimethyl-1,3-dioxo-2-phenyl-2,3,3a,4,6,8,9,10,10a,10b-decahydro-1H-oxepino[4,3-e]isoindol-9-yl benzylcarbamate

    References

    1. Basu S, et al. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6805-10.

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