Wyeth-1 | hAMCase inhibitor | Probechem Biochemicals

Chemical Structure : Wyeth-1

Wyeth-1 (hAMCase inhibitor 1)

Catalog No.: PC-72373Not For Human Use, Lab Use Only.

Wyeth-1 (hAMCase inhibitor 1) is a potent, selective inhibitor of human acidic mammalian chitinase (hAMCase) with IC50 of 210 nM, 20-fold selectivity over hCHIT1.

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Biological Activity

Wyeth-1 (hAMCase inhibitor 1) is a potent, selective inhibitor of human acidic mammalian chitinase (hAMCase) with IC50 of 210 nM, 20-fold selectivity over hCHIT1.
Wyeth-1 reduced AMCase enzymatic activity in the bronchoalveolar lavage fluid in allergen-challenged mice after oral dosing.

Physicochemical Properties

M.Wt	367.251
Formula	C14H19BrN6O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-(2-(4-bromophenoxy)ethyl)piperazin-1-yl)-1H-1,2,4-triazol-5-amine

References

1. Derek C Cole, et al. J Med Chem. 2010 Aug 26;53(16):6122-8.

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Wyeth-1 (hAMCase inhibitor 1)

Biological Activity

Physicochemical Properties

References

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