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Chemical Structure : X20404
Catalog No.: PC-22093Not For Human Use, Lab Use Only.
X20404 is a small molecule inhibitor of the thioesterase activity of Mtb polyketide synthase 13 (Pks13) with IC50 of 0.4 uM in the Pks13-TE enzyme assay.
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X20404 is a small molecule inhibitor of the thioesterase activity of Mtb polyketide synthase 13 (Pks13) with IC50 of 0.4 uM in the Pks13-TE enzyme assay.
X20404 has a favorable pharmacokinetic profile and demonstrated efficacy in an acute mouse model of tuberculosis (TB) infection.
| M.Wt | 457.53 | |
| Formula | C26H27N5O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Krieger IV, et al. ACS Infect Dis. 2024 Apr 5. doi: 10.1021/acsinfecdis.3c00592.
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