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Chemical Structure : XAV939
CAS No.: 284028-89-3
Catalog No.: PC-21186Not For Human Use, Lab Use Only.
XAV939 is a potent small molecule inhibitor of Tankyrases with IC50 of 5 nM and 2 nM for TNKS1 and TNKS2, respectively, selectively inhibits beta-catenin-mediated transcription.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $198 | In stock | |
| 100 mg | $298 | In stock | |
| 200 mg | $458 | In stock | |
| 1 g | Get quote |
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XAV939 is a potent small molecule inhibitor of Tankyrases with IC50 of 5 nM and 2 nM for TNKS1 and TNKS2, respectively, selectively inhibits beta-catenin-mediated transcription.
XAV939 stimulates beta-catenin degradation by stabilizing axin.
XAV939 stabilize Axin2 levels in oligodendrocyte progenitor cells (OLPs) from brain and spinal cord and accelerated their differentiation and myelination after hypoxic and demyelinating injury.
XAV939 increases Axin1 and Axin2 protein levels and attenuates Wnt-induced transcriptional responses in several breast cancer lines.
XAV939 attenuates Wnt3a induced cell migration in MDA-MB-231 cells.
XAV939 is an inhibitor of canonical WNT signalling.
| M.Wt | 312.31 | |
| Formula | C14H11F3N2OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
2-(4-(Trifluoromethyl)phenyl)-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one |
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1. Huang SM, et al. Nature. 2009 Oct 1;461(7264):614-20.
2. Karlberg T, et al. J Med Chem. 2010 Jul 22;53(14):5352-5.
3. Fancy SP, et al. Nat Neurosci. 2011 Jun 26;14(8):1009-16.
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