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Chemical Structure : XL-281
Catalog No.: PC-61525Not For Human Use, Lab Use Only.
XL-281 (BMS 908662) is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models.
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XL-281 (BMS 908662) is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models.
XL-281 (BMS 908662) demonstrates biological activity by modulation of the RAF pathway in tumor and surrogate tissue, with decreases in cell proliferation and increases in apoptosis.
| M.Wt | 462.89 | |
| Formula | C24H19ClN4O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Callahan MK, et al. Cancer Immunol Res. 2014 Jan;2(1):70-9.
2. Belum VR, et al. Cancer. 2015 Jan 1;121(1):60-8.
3. Dickson MA, et al. Invest New Drugs. 2015 Apr;33(2):349-56.
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