XL228 | Multikinase inhibitor | Probechem Biochemicals

Chemical Structure : XL228

CAS No.: 898280-07-4

XL228 (XL-228)

Catalog No.: PC-26878Not For Human Use, Lab Use Only.

XL228 (XL-228) is a potent, multi-targeted tyrosine kinase inhibitor with IC50s of 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src and Lyn, respectively.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
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Biological Activity

XL228 (XL-228) is a potent, multi-targeted tyrosine kinase inhibitor with IC50s of 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src and Lyn, respectively.

Physicochemical Properties

M.Wt	437.55
Formula	C22H31N9O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-(5-Cyclopropyl-1H-pyrazol-3-yl)-N2-((3-isopropylisoxazol-5-yl)methyl)-6-(4-methylpiperazin-1-yl)pyrimidine-2,4-diamine

References

1. Noronha G, et al. Curr Top Med Chem. 2008;8(10):905-21.

2. Cortes J, et al. Blood 2008 112:3232

3. Douglas O, et al. Mol Cancer Ther 2009;8(12 Suppl):C192.

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XL228 (XL-228)

Biological Activity

Physicochemical Properties

References

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