XL495 | PKMYT1 inhibitor | Probechem Biochemicals

Chemical Structure : XL495

XL495 (XL-495)

Catalog No.: PC-26487Not For Human Use, Lab Use Only.

XL495 is a potent, selective and orally bioavailable PKMYT1 inhibitor, demonstrates dose-dependent antitumor activity, inhibits phosphorylation of CDK1 at Thr14, and induces phosphorylation of KAP1 at Ser824 in CDX tumors.

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Biological Activity

Physicochemical Properties

M.Wt	308.34
Formula	C17H16N4O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	7-amino-8-(3-hydroxy-2,6-dimethylphenyl)quinoxaline-6-carboxamide

References

1. Zhu J, et al. J Org Chem. 2026 Apr 6. doi: 10.1021/acs.joc.6c00304.

2. Dana Gwinn, et al. Cancer Res (2025) 85 (8_Supplement_1): 1733.

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XL495 (XL-495)

Biological Activity

Physicochemical Properties

References

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