XLY-1 | PARP7 inhibitor | Probechem Biochemicals

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Chemical Structure : XLY-1

XLY-1 (XYL1)

Catalog No.: PC-22466Not For Human Use, Lab Use Only.

XYL-1 is a highly potent, selective PARP7 inhibitor with IC50 of 0.6 nM, weak inhibitory effect on PARP1 (IC50 >1 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

XYL-1 is a highly potent, selective PARP7 inhibitor with IC50 of 0.6 nM, weak inhibitory effect on PARP1 (IC50 >1 uM).
XYL-1 could enhance the type Ⅰ interferon signaling in vitro.
XYL-1 shows higher inhibitory activity (IC50 = 0.6 nM) than that of RBN-2397 (IC50 = 6.0 nM).
XYL-1 (50 mg/kg administered orally twice daily) could significantly inhibit tumor growth (TGI: 76.5 %) in CT26 tumor-bearing mice, restores type Ⅰ interferon signaling and promote T cell infiltration in tumor tissues.

Physicochemical Properties

M.Wt	508.43
Formula	C19H22F6N8O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-((6-oxo-5-(trifluoromethyl)-1,6-dihydropyridazin-4-yl)amino)butyl)-4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazine-1-carboxamide

References

1. Jieping Yang, et al. Bioorg Chem. 2024 Jul:148:107469.

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XLY-1 (XYL1)

Biological Activity

Physicochemical Properties

References

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