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Chemical Structure : XLY-1
Catalog No.: PC-22466Not For Human Use, Lab Use Only.
XYL-1 is a highly potent, selective PARP7 inhibitor with IC50 of 0.6 nM, weak inhibitory effect on PARP1 (IC50 >1 uM).
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XYL-1 is a highly potent, selective PARP7 inhibitor with IC50 of 0.6 nM, weak inhibitory effect on PARP1 (IC50 >1 uM).
XYL-1 could enhance the type Ⅰ interferon signaling in vitro.
XYL-1 shows higher inhibitory activity (IC50 = 0.6 nM) than that of RBN-2397 (IC50 = 6.0 nM).
XYL-1 (50 mg/kg administered orally twice daily) could significantly inhibit tumor growth (TGI: 76.5 %) in CT26 tumor-bearing mice, restores type Ⅰ interferon signaling and promote T cell infiltration in tumor tissues.
| M.Wt | 508.43 | |
| Formula | C19H22F6N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jieping Yang, et al. Bioorg Chem. 2024 Jul:148:107469.
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