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Chemical Structure : XM-U-14
Catalog No.: PC-22785Not For Human Use, Lab Use Only.
XM-U-14 is a highly potent, selective and efficacious USP7 PROTAC degrader with DC50 of 0.7 nM in RS4;11 cell, Dmax of 93.1%.
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XM-U-14 is a highly potent, selective and efficacious USP7 PROTAC degrader with DC50 of 0.7 nM in RS4;11 cell, Dmax of 93.1%.
XM-U-14 significantly upregulated the levels of p53 and p21 in a time and dose-dependent manner.
XM-U-14 showed significant cell growth inhibition with IC50 values of 0.5 nM and 8.3 nM in RS4;11 cells and Reh cells, respectively.
XM-U-14 (1, 10, 100, and 1000 nM) induced apoptosis and cycle arrest in RS4;11 cells.
XM-U-14 (5, 10 mg/kg and 20 mg/kg for 18 days) significantly decreased the levels of USP7 protein in the RS4;11 tumor tissue, exhibited effective tumor growth inhibition in the RS4;11 xenograft tumor model.
| M.Wt | 1064.32 | |
| Formula | C58H69N11O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Miaomiao Xu, et al. J Med Chem. 2024 Jul 19. doi: 10.1021/acs.jmedchem.4c01134.
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