XMD16-5 |CAS:1345098-78-3 Probechem Biochemicals

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Chemical Structure : XMD16-5

CAS No.: 1345098-78-3

XMD16-5 (XMD 16-5)

Catalog No.: PC-42339Not For Human Use, Lab Use Only.

XMD16-5 is a potent Ack1 (TNK2) inhibitor with IC50 of 0.38 uM in ELISA assay.

Packing	Price	Stock
5 mg	$98	In stock
10 mg	$158	In stock
25 mg	$258	In stock
50 mg	$398	In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

XMD16-5 is a potent Ack1 (TNK2) inhibitor with IC50 of 0.38 uM in ELISA assay.
XMD16-5 exhibits potent inhibition of growth of the TNK2 mutant expressing cell lines with IC50s of 16 nM and 77 nM for the D163E and R806Q mutations.

Physicochemical Properties

M.Wt	416.47566
Formula	C23H24N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 29 mg/mL
Chemical Name/SMILES	6H-Pyrimido[4,5-b][1,4]benzodiazepin-6-one, 5,11-dihydro-2-[[4-(4-hydroxy-1-piperidinyl)phenyl]amino]-11-methyl-

References

1. Miduturu CV, et al. Chem Biol. 2011 Jul 29;18(7):868-79.

2. Maxson JE, et al. Cancer Res. 2016 Jan 1;76(1):127-38.

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XMD16-5 (XMD 16-5)

Biological Activity

Physicochemical Properties

References

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