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Chemical Structure : XMD8-87
CAS No.: 1234480-46-6
Catalog No.: PC-35146Not For Human Use, Lab Use Only.
XMD8-87 (Ack1 inhibitor B19) is a potent Ack1 inhibitor with Kd of 15 nM, inhibits EGF-induced autophosphorylation in HEK293 cells at 2 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $88 | In stock | |
| 10 mg | $138 | In stock | |
| 25 mg | $228 | In stock | |
| 50 mg | $388 | In stock | |
| 100 mg | Get quote |
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XMD8-87 (Ack1 inhibitor B19) is a potent Ack1 inhibitor with Kd of 15 nM, inhibits EGF-induced autophosphorylation in HEK293 cells at 2 uM.
XMD8-87 completely inhibits A549 cancer cell growth, and partially inhibited EGF-stimulated cancer cell growth at 10 uM.
XMD8-87 is a potent, selective Ack1 (TNK2) inhibitor with IC50 of 1.9 uM in ELISA assays.
XMD8-87 potently block proliferation of TNK2 mutant cell lines, shows IC50s of 38 nM and 113 nM for the D163E and R806Q mutations.
| M.Wt | 445.527 | |
| Formula | C24H27N7O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-11-methyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one |
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1. Miduturu CV, et al. Chem Biol. 2011 Jul 29;18(7):868-79.
2. Mahajan K, et al. Cancer Lett. 2013 Sep 28;338(2):185-92.
3. Maxson JE, et al. Cancer Res. 2016 Jan 1;76(1):127-38.
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