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Chemical Structure : XMU-MP-2
CAS No.: 2031152-10-8
Catalog No.: PC-61652Not For Human Use, Lab Use Only.
XMU-MP-2 is a potent and selective BRK/PTK6 (breast tumor kinase) inhibitor with biochemical IC50 of 3.2 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
| 25 mg | $898 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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XMU-MP-2 is a potent and selective BRK/PTK6 (breast tumor kinase) inhibitor with biochemical IC50 of 3.2 nM.
XMU-MP-2 inhibits the autophosphorylation of BRK Y342 in dose-dependent manner (maximum inhibition at 500 nM), abolishes phosphorylation levels of STAT3 Y705 and STAT5 Y694.
XMU-MP-2 blocks proliferation and survival of BRK-transformed Ba/F3 cells with IC50 of 29.7 nM.
XMU-MP-2 cooperates strongly with HER2 inhibitor or ER blockade to block breast cancer cell proliferation in vitro and in vivo.
| M.Wt | 618.665 | |
| Formula | C32H33F3N8O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-(7-((6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)amino)-1-methyl-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide |
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1. Jiang J, et al. Cancer Res. 2017 Jan 1;77(1):175-186.
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