Chemical Structure : XOB
CAS No.:
3025216-14-9
XOB
(5-HT2A/VGSC antagonist)
Catalog No.: PC-22491Not For Human Use, Lab Use Only.
XOB is a selective antagonist of 5-HT2A receptor and voltage-gated sodium channels, simultaneously antagonizes 5-HT2A receptors and blocks sodium voltage-gated sodium channels (VGSCs).
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
XOB is a selective antagonist of 5-HT2A receptor and voltage-gated sodium channels, simultaneously antagonizes 5-HT2A receptors and blocks sodium voltage-gated sodium channels (VGSCs).
XOB antagonizes 5-HT-stimulated, Gq-mediated, calcium flux at 5-HT2A receptors at low micromolar concentrations while displaying negligible affinity and activity at 5-HT1A, 5-HT2B, and 5-HT2C receptors.
XOB simultaneously antagonizes two key therapeutic targets of bipolar disorder, 5-HT2A receptors and voltage-gated sodium channels (VGSCs), in heterologous cells, and inhibits the intrinsic excitability of mouse prefrontal cortex layer V pyramidal neurons in brain slices.
Physicochemical Properties
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M.Wt
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492.50
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Formula
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C26H38BrNO3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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N-(4-bromo-2,5-dimethoxyphenethyl)-6-(4-phenylbutoxy)hexan-1-amine
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References
1. Nicholas Denomme, et al. Mol Pharmacol. 2024 May 31:MOLPHARM-AR-2023-000837.
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