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Chemical Structure : XOB
Catalog No.: PC-22491Not For Human Use, Lab Use Only.
XOB is a selective antagonist of 5-HT2A receptor and voltage-gated sodium channels, simultaneously antagonizes 5-HT2A receptors and blocks sodium voltage-gated sodium channels (VGSCs).
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XOB is a selective antagonist of 5-HT2A receptor and voltage-gated sodium channels, simultaneously antagonizes 5-HT2A receptors and blocks sodium voltage-gated sodium channels (VGSCs).
XOB antagonizes 5-HT-stimulated, Gq-mediated, calcium flux at 5-HT2A receptors at low micromolar concentrations while displaying negligible affinity and activity at 5-HT1A, 5-HT2B, and 5-HT2C receptors.
XOB simultaneously antagonizes two key therapeutic targets of bipolar disorder, 5-HT2A receptors and voltage-gated sodium channels (VGSCs), in heterologous cells, and inhibits the intrinsic excitability of mouse prefrontal cortex layer V pyramidal neurons in brain slices.
| M.Wt | 492.50 | |
| Formula | C26H38BrNO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Nicholas Denomme, et al. Mol Pharmacol. 2024 May 31:MOLPHARM-AR-2023-000837.
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