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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Sodium Channel-XPC-5462
XPC-5462

Chemical Structure : XPC-5462

CAS No.: 2230145-14-7

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XPC-5462 (XPC5462)

Catalog No.: PC-21779Not For Human Use, Lab Use Only.

XPC-5462 is a potent, selective dual inhibitor of NaV1.6 and NaV1.2 with IC50 of 10.9 nM and 10.3 nM, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    XPC-5462 is a potent, selective dual inhibitor of NaV1.6 and NaV1.2 with IC50 of 10.9 nM and 10.3 nM, respectively.
    XPC-5462 displays weak activity against NaV1.7, and no significant effect on other NaV subtypes.
    XPC-7224 (150 nM) significantly inhibits AP firing from pyramidal cells but not fast spiking interneurons. XPC-7224 inhibits neocortical ex vivo seizure-like events.

    Physicochemical Properties

    M.Wt 486.50
    Formula C20H18F4N4O2S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-((2-(azetidin-1-ylmethyl)-3,6-difluorobenzyl)amino)-2,6-difluoro-N-(thiazol-4-yl)benzenesulfonamide

    References

    1. Samuel J Goodchild, et al. ACS Chem Neurosci. 2024 Feb 15.

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