XPC-5462 | NaV1.2/1.6 inhibitor | Probechem Biochemicals

Chemical Structure : XPC-5462

XPC-5462 (XPC5462)

Catalog No.: PC-21779Not For Human Use, Lab Use Only.

XPC-5462 is a potent, selective dual inhibitor of NaV1.6 and NaV1.2 with IC50 of 10.9 nM and 10.3 nM, respectively.

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Biological Activity

XPC-5462 is a potent, selective dual inhibitor of NaV1.6 and NaV1.2 with IC50 of 10.9 nM and 10.3 nM, respectively.
XPC-5462 displays weak activity against NaV1.7, and no significant effect on other NaV subtypes.
XPC-7224 (150 nM) significantly inhibits AP firing from pyramidal cells but not fast spiking interneurons. XPC-7224 inhibits neocortical ex vivo seizure-like events.

Physicochemical Properties

M.Wt	486.50
Formula	C20H18F4N4O2S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((2-(azetidin-1-ylmethyl)-3,6-difluorobenzyl)amino)-2,6-difluoro-N-(thiazol-4-yl)benzenesulfonamide

References

1. Samuel J Goodchild, et al. ACS Chem Neurosci. 2024 Feb 15.

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XPC-5462 (XPC5462)

Biological Activity

Physicochemical Properties

References

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