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XPC-6444

Chemical Structure : XPC-6444

CAS No.: 2230144-21-3

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XPC-6444 (XPC6444)

Catalog No.: PC-73070Not For Human Use, Lab Use Only.

XPC-6444 (XPC6444) is a potent, CNS-penetrant, isoform-selective NaV1.6 inhibitor with IC50 of 41 nM, also potently blocks NaV1.2 (IC50=125 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    XPC-6444 (XPC6444) is a potent, CNS-penetrant, isoform-selective NaV1.6 inhibitor with IC50 of 41 nM, also potently blocks NaV1.2 (IC50=125 nM).
    XPC-6444 displays no significant inhibition against NaV1.1 and NaV1.5 (IC50>10 uM).
    XPC-6444 produced potent anticonvulsant activity in mouse seizure models, including a direct current maximal electroshock seizure assay.

    Physicochemical Properties

    M.Wt 498.583
    Formula C22H25F3N4O2S2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-((2-((Tert-butyl(methyl)amino)methyl)-6-fluorobenzyl)amino)-2,6-difluoro-N-(thiazol4-yl)benzenesulfonamide

    References

    1. Focken T, et al. J Med Chem. 2019 Sep 17. doi: 10.1021/acs.jmedchem.9b01032.

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