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You are here:Home-Chemical Inhibitors & Agonists-Membrane Transporter/Ion Channel-Sodium Channel-XPC-7224
XPC-7224

Chemical Structure : XPC-7224

CAS No.:

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XPC-7224 (XPC7224)

Catalog No.: PC-21778Not For Human Use, Lab Use Only.

XPC-7224 is a potent, selective NaV1.6 inhibitor with IC50 of 78 nM and 130 nM for human and mouse NaV1.6, respectively, interacts with the inactivated state of the channel.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

XPC-7224 is a potent, selective NaV1.6 inhibitor with IC50 of 78 nM and 130 nM for human and mouse NaV1.6, respectively, interacts with the inactivated state of the channel.
XPC-7224 is >100-fold more potent than all other NaV subtypes.
XPC-7224 (500 nM) significantly inhibits AP firing from pyramidal cells but not fast spiking interneurons.
NaV1.6 R1626A displays a > 1000-fold drop in potency for XPC-7224.

Physicochemical Properties

M.Wt 483.61
Formula C25H30FN5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-fluoro-5-methyl-4-(methyl(1-(1-phenylethyl)piperidin-4-yl)amino)-N-(pyrimidin-2-yl)benzenesulfonamide

References

1. Samuel J Goodchild, et al. ACS Chem Neurosci. 2024 Feb 15.

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