XX-650-23 is a small molecule inhibitor of CREB, blocks CREB/CBP interaction (IC50=3.2 uM) and disrupts CREB-driven gene expression.
XX-650-23 suppresses AML cell lines growth with IC50 of 0.87-2.3 uM, specifically disrupts CREB-driven transcription, induces apoptosis and cell-cycle arrest.
XX-650-23 significantly increases survival of cell line- and patient-derived xenograft mice with no toxicity to normal hematopoietic cells or animals.
Physicochemical Properties
M.Wt
288.306
Formula
C18H12N2O2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-(4-cyanophenyl)-3-hydroxy-2-naphthamide
References
1. Mitton B, et al. Leukemia. 2016 Dec;30(12):2302-2311.
2. François S, et al. J Virol. 2016 Sep 12;90(19):8686-97.
