Catalog No.: PC-21453Not For Human Use, Lab Use Only.
XY-4083 (AVL-3288) is a selective type I α7 nAChR positive allosteric modulator (PAM), evokes positive modulation of EC5 currents induced by acetylcholine ACh, choline, and nicotine with EC50 of 0.7, 0.6 and 0.5 uM, respectively.
XY-4083 (AVL-3288) is a selective type I α7 nAChR positive allosteric modulator (PAM), evokes positive modulation of EC5 currents induced by acetylcholine ACh, choline, and nicotine with EC50 of 0.7, 0.6 and 0.5 uM, respectively. XY-4083 does not evoke modulation of EC5-evoked currents at human α4β2, rat α3β4, and mouse α1β1γδ nAChR subtypes or human 5-HT3A receptors expressed in oocytes. XY-4083 also evokes positive modulation of choline-evoked currents in SH-SY5Y cells transfected with α7 nAChRs. XY-4083 corrects sensory-gating deficits and improves working memory, effects consistent with cognitive enhancement in rodent models.
