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Chemical Structure : XY-4083
CAS No.: 917837-54-8
Catalog No.: PC-21453Not For Human Use, Lab Use Only.
XY-4083 (AVL-3288) is a selective type I α7 nAChR positive allosteric modulator (PAM), evokes positive modulation of EC5 currents induced by acetylcholine ACh, choline, and nicotine with EC50 of 0.7, 0.6 and 0.5 uM, respectively.
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|---|---|---|---|
| 10 mg | $138 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $368 | In stock | |
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| 1 g | Get quote |
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XY-4083 (AVL-3288) is a selective type I α7 nAChR positive allosteric modulator (PAM), evokes positive modulation of EC5 currents induced by acetylcholine ACh, choline, and nicotine with EC50 of 0.7, 0.6 and 0.5 uM, respectively.
XY-4083 does not evoke modulation of EC5-evoked currents at human α4β2, rat α3β4, and mouse α1β1γδ nAChR subtypes or human 5-HT3A receptors expressed in oocytes.
XY-4083 also evokes positive modulation of choline-evoked currents in SH-SY5Y cells transfected with α7 nAChRs.
XY-4083 corrects sensory-gating deficits and improves working memory, effects consistent with cognitive enhancement in rodent models.
| M.Wt | 388.25 | |
| Formula | C19H15Cl2N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(E)-N-(4-chlorophenyl)-3-((4-chlorophenyl)amino)-2-(3-methylisoxazol-5-yl)acrylamide |
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1. Ng HJ, et al. Proc Natl Acad Sci U S A. 2007.
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