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XYD270

Chemical Structure : XYD270

CAS No.:

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XYD270 (XYD-270)

Catalog No.: PC-26219Not For Human Use, Lab Use Only.

XYD270 is a potent, selective, and orally efficacious BRD9 PROTAC degrader with DC50 of 0.082 nM and 3.9 nM in HS-SY-II cells and MV4;11 cells respectively.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

XYD270 is a potent, selective, and orally efficacious BRD9 PROTAC degrader with DC50 of 0.082 nM and 3.9 nM in HS-SY-II cells and MV4;11 cells respectively.
XYD270 does not reduce BRD4 or BRD7 protein levels.
XYD270 demonstrates potent antiproliferative activity with IC50 values of 50 nM in MV4;11 cells and 1.65 μM in HS-SY-II cells.
XYD270 (10 mg/kg once daily) achieved 54% tumor growth inhibition in MV4;11 xenograft models.

Physicochemical Properties

M.Wt 692.86
Formula C40H48N6O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-((4-(4-((1-(4-(3-Acetylindolizin-1-yl)-2,6-dimethoxybenzyl)piperidin-4-yl)methyl)piperazin-1-yl)phenyl)amino)piperidine-2,6-dione

References

1. Huang Y, et al. J Med Chem. 2026 Mar 4. doi: 10.1021/acs.jmedchem.5c02858.

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