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Chemical Structure : XZH-5
Catalog No.: PC-61667Not For Human Use, Lab Use Only.
XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes.
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XZH-5 is a small moelcule that inhibits constitutive and interleukin-6-induced STAT3 phosphorylation, inhibits STAT3 DNA binding ability and downregulation of STAT3 downstream genes.
XZH-5 inhibits downregulation of STAT3 downstream genes, such as Bcl-2, Bcl-xL, Cyclin D1 and Survivin,.
XZH-5 demonstrates blockade of STAT3 phosphorylation in human rhabdomyosarcoma cells with apoptosis and suppresses colony-forming ability and cell migration.
XZH-5 blocks IL-6-induced STAT3 phosphorylation and nuclear translocation but not the stimulation of STAT1 phosphorylation by IFN-γ.
| M.Wt | 537.463 | |
| Formula | C22H25F6N5O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu Y, et al. Apoptosis. 2011 May;16(5):502-10.
2. Liu A, et al. Cancer Sci. 2011 Jul;102(7):1381-7.
3. Liu A, PLoS One. 2012;7(10):e46624.
4. Daka P, et al. Bioorg Med Chem. 2015 Mar 15;23(6):1348-55.
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