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Chemical Structure : Xanomeline oxalate
CAS No.: 141064-23-5
Catalog No.: PC-43517Not For Human Use, Lab Use Only.
Xanomeline oxalate (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens).
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|---|---|---|---|
| 5 mg | $68 | In stock | |
| 25 mg | $168 | In stock | |
| 100 mg | $458 | In stock | |
| 500 mg | Get quote |
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Xanomeline oxalate (LY246708, NNC 110232) is a potent, specific M1 muscarinic agonist with functional selectivity for M1 receptor (binding IC50 of 6 pM in the rabbit vas deferens); displays low affinity for M2 receptors in guinea pig atria (EC50=3 uM); xanomeline increases striatal levels of dopamine metabolites, presumably by acting at M1 heteroreceptors on dopamine neurons to increase dopamine release in vivo; inhibits ex vivo binding of muscarinic radioligands to homogenates of brain and the inhibition of ex vivo binding occurred in the same dose range as increases in DOPAC levels; xanomeline is selective agonist for M1 over M2 and M3 receptors in vivo in rats.
Alzheimer Disease
Phase 3 Discontinued
| M.Wt | ||
| Formula | C16H25N3O5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl-, ethanedioate (1:1) |
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1. Shannon HE, et al. J Pharmacol Exp Ther. 1994 Apr;269(1):271-81.
2. Sauerberg P, et al. J Med Chem. 1992 Jun 12;35(12):2274-83.
3. Bymaster FP, et al. J Pharmacol Exp Ther. 1994 Apr;269(1):282-9.
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