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Y020-3945

Chemical Structure : Y020-3945

CAS No.: 1158196-20-3

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Y020-3945 (Y 020-3945)

Catalog No.: PC-21660Not For Human Use, Lab Use Only.

Y020-3945 is a selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor with IC50 of 0.53 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Y020-3945 is a selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor with IC50 of 0.53 uM.
Y020-3945 exhibits partial inhibition of CLK1, does not exhibit significant inhibitory effects on other CMGC kinases.
Y020-3945 reduces tau phosphorylation via DYRK1A inhibition, decreases phosphorylated Thr181, Thr212, and Thr217 expression at 30 uM in HEK-293 cell model.
Y020-3945 facilitates tubulin assembly via DYRK1A inhibition, shows low cytotoxicity and inhibit the inflammatory response.

Physicochemical Properties

M.Wt 349.78
Formula C18H12ClN5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((2-chlorophenyl)amino)-5-(pyridin-4-yl)pyrido[2,3-d]pyrimidin-4(3H)-one

References

1. Yi-Wen Wu, et al. Int J Biol Macromol. 2023 Dec 30:129074.

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