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Chemical Structure : Y020-3945
Catalog No.: PC-21660Not For Human Use, Lab Use Only.
Y020-3945 is a selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor with IC50 of 0.53 uM.
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Y020-3945 is a selective dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) inhibitor with IC50 of 0.53 uM.
Y020-3945 exhibits partial inhibition of CLK1, does not exhibit significant inhibitory effects on other CMGC kinases.
Y020-3945 reduces tau phosphorylation via DYRK1A inhibition, decreases phosphorylated Thr181, Thr212, and Thr217 expression at 30 uM in HEK-293 cell model.
Y020-3945 facilitates tubulin assembly via DYRK1A inhibition, shows low cytotoxicity and inhibit the inflammatory response.
| M.Wt | 349.78 | |
| Formula | C18H12ClN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yi-Wen Wu, et al. Int J Biol Macromol. 2023 Dec 30:129074.
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