Catalog No.: PC-43036Not For Human Use, Lab Use Only.
FAK inhibitor Y15 is a small molecule inhibitor targeting the main autophosphorylation site of FAK, specifically blocks phosphorylation of Y397-FAK (IC50=1 uM) and total phosphorylation of FAK.
FAK inhibitor Y15 is a small molecule inhibitor targeting the main autophosphorylation site of FAK, specifically blocks phosphorylation of Y397-FAK (IC50=1 uM) and total phosphorylation of FAK.
Y15 does not significantly decrease kinase activity of the other kinases (Pyk2 autophosphorylation).
Y15 directly and specifically decreases Y397-phosphorylation of FAK in vitro, inhibits cancer cell viability in vitro, causes detachment, decreases cell adhesion and blocks tumor growth in vivo.
Physicochemical Properties
M.Wt
284.0142
Formula
C6H14Cl4N4
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
H2O: ≥ 59 mg/mL
Chemical Name/SMILES
1,2,4,5-Benzenetetramine, hydrochloride (1:4)
References
1. Hochwald SN, et al. Cell Cycle. 2009 Aug;8(15):2435-43.
2. Zheng D, et al. Mol Carcinog. 2010 Feb;49(2):200-9.
3. Beierle EA, et al. Cell Cycle. 2010 Mar 1;9(5):1005-15.
4. Golubovskaya VM, et al. J Med Chem. 2008 Dec 11;51(23):7405-16.
