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Y2R antagonist SF-11

Chemical Structure : Y2R antagonist SF-11

CAS No.: 443292-81-7

Y2R antagonist SF-11 (SF11)

Catalog No.: PC-26143Not For Human Use, Lab Use Only.

Y2R antagonist SF-11 is potent, selective and brain penetrant antagonist of Neuropeptide Y Y2 Receptor (Y2R) with IC50 of 199 nM, induces antidepressant-like effect in rats.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Y2R antagonist SF-11 is potent, selective and brain penetrant antagonist of Neuropeptide Y Y2 Receptor (Y2R) with IC50 of 199 nM, induces antidepressant-like effect in rats.

Physicochemical Properties

M.Wt 446.61
Formula C27H30N2O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(4-ethoxyphenyl)-4-(hydroxydiphenylmethyl)-1-piperidinecarbothioamide

References

1. Domin H, et al. ACS Chem Neurosci. 2019 Aug 21;10(8):3454-3463.

2. Brothers SP, et al. Mol Pharmacol. 2010;77(1):46-57.

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