YAP-TEAD inhibitor BY03

Chemical Structure : YAP-TEAD inhibitor BY03

Catalog No.: PC-23113Not For Human Use, Lab Use Only.

BY03 is a small molecule inhibitor of YAP-TEAD interaction with IC50 of 1.5 uM in TEAD-dependent luciferase assay in overexpressing the TEAD luciferase plasmid in HEK293T.

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Biological Activity

BY03 is a small molecule inhibitor of YAP-TEAD interaction with IC50 of 1.5 uM in TEAD-dependent luciferase assay in overexpressing the TEAD luciferase plasmid in HEK293T.
BY03 directly bind to TEAD1 with SPR KD value of 9.4 μM.
BY03 (1-15 uM) inhibits YAP-TEAD target genes (CYR61, AMOT) in HEK293T cells.

Physicochemical Properties

M.Wt	484.61
Formula	C29H28N2O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-dibenzyl-2-(N-(o-tolyl)phenylsulfonamido)acetamide

References

1. Kim J, et al. Cancers (Basel). 2021 Aug 23;13(16):4246.

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