YAP1 inhibitor CA3 (CA3, CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/TEAD transcriptional activity
YAP1 inhibitor CA3 (CIL56) also demonstrates strong inhibitory effects on esophageal adenocarcinoma cell growth especially on YAP1 high-expressing esophageal adenocarcinoma cells both in vitro and in vivo.
YAP1 inhibitor CA3 (CIL56) can effectively suppress radiation-resistant cancer stem cell (CSC) properties and aggressive phenotype by inhibiting proliferation, inducing apoptosis, reducing tumor sphere formation; synergistically inhibits cancer cell growth combined with 5-FU.
YAP1 inhibitor CA3 (CIL56) triggers nonapoptotic cell death, a potent and selective probe of ferroptosis.
YAP1 inhibitor CA3 (CIL56) stimulates the activity of ACC1, inhibits the normal breakdown of fatty acids by mitochondrial β-oxidation.
