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Chemical Structure : YAP inhibitor JM7
Catalog No.: PC-49416Not For Human Use, Lab Use Only.
JM7 is a small-molecule that inhibits TEAD palmitoylation and stability, affects YAP-TEAD interaction and inhibits YAP transcriptional activity and impairs proliferation, colony formation and migration of breast and ovarian cancer cells.
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JM7 is a small-molecule that inhibits TEAD palmitoylation and stability, affects YAP-TEAD interaction and inhibits YAP transcriptional activity and impairs proliferation, colony formation and migration of breast and ovarian cancer cells.
JM7 inhibits YAP transcriptional activity in a dose-dependent manner in cellular reportor assays, also inhibits YAP target gene expression, significantly downregulates the expression of both CTGF and CYR61 transcript levels in MDA-MB- 231 and OVCAR-8 cells.
JM7 interferes with YAP/TAZTEAD interaction, directly engages TEAD1-4 in cells.
JM7 (2 uM) inhibits proliferation, colony forming ability and migration of the MDA-MB-231 and OVCAR-8 cancer cells.
| M.Wt | 396.399 | |
| Formula | C21H20N2O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gridnev A, et al. Front Oncol. 2022 Nov 29;12:1021823.
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