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YH12852

Chemical Structure : YH12852

CAS No.: 1394316-91-6

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YH12852 (YH 12852)

Catalog No.: PC-62093Not For Human Use, Lab Use Only.

YH12852 is a potent, highly selective 5-HT4 receptor agonist with pKi of 10.3, exhibits more potent agonistic activity (pEC50=11.4) than both tegaserod and prucalopride.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YH12852 is a potent, highly selective 5-HT4 receptor agonist with pKi of 10.3, exhibits more potent agonistic activity (pEC50=11.4) than both tegaserod and prucalopride.
    YH12852 exhibits high selectivity for the 5-HT4 receptor over other 5-HT receptor subtypes and non-5-HT receptors.
    YH12852 significantly improves both upper and lower gastrointestinal motility in a guinea pig model of postoperative ileus.

    Physicochemical Properties

    M.Wt 399.46
    Formula C19H25N7O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-N-(1-(2-((4-amino-3-nitrophenyl)amino)-6-propylpyrimidin-4-yl)pyrrolidin-3-yl)acetamide

    References

    1. Hussain Z, et al. Neurogastroenterol Motil. 2017 Oct;29(10):1-6.

    2. Jeong EJ, et al. Br J Pharmacol. 2018 Feb;175(3):485-500.

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