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YHD-26

Chemical Structure : YHD-26

CAS No.:

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YHD-26 (YHD26)

Catalog No.: PC-28011Not For Human Use, Lab Use Only.

YHD-26 is a novel ferroptosis inducer and dul GPX4/PARP inhibitor, inhibits PARP (IC50=92 nM) and binds GPX4 (KD=23.4 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YHD-26 is a novel ferroptosis inducer and dual GPX4/PARP inhibitor, inhibits PARP (IC50=92 nM) and binds GPX4 (KD=23.4 uM).
YHD-26 exerts potent antiproliferative effects, induces ferroptosis, and impairs DNA damage repair, resulting in G2/M arrest in MDA-MB-468 and 4T1 cells.
YHD-26 inhibited GPX4 and PARP, validating its in vivo antitumor efficacy and dual-target engagement in 4T xenograft mouse model。

Physicochemical Properties

M.Wt 455.54
Formula C25H21N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-(4-(1-(4-ethynylthiazole-2-carbonyl)piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide

References

1. Bao H, et al. Biochem Pharmacol. 2026 Sep 4:118433.

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