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Chemical Structure : YHV98-4
CAS No.: 132858-26-5
Catalog No.: PC-38294Not For Human Use, Lab Use Only.
YHV98-4 is a selective inhibitor of proton-selective ion channel Hv1 with IC50 of 0.7 uM.
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| 10 mg | $458 | In stock | |
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YHV98-4 is a selective inhibitor of proton-selective ion channel Hv1 with IC50 of 0.7 uM.
YHV98-4 displays no inhibitory effects against other channels containing VSDs, including hERG, KCNQ2, BK, and Nav1.7 channel.
YHV98-4 did not inhibit transient receptor potential V1 (TRPV1) or A1 (TRPA1) at 20 uM, which also contains VSD-like domain.
YHV98-4 restores impaired ROS-mediated inflammatory pathway, restores impaired ROS-SHP-1-PI3K/pAKT-CXCL1 pathway and attenuates morphine-induced hyperalgesia and tolerance.
| M.Wt | 332.802 | |
| Formula | C16H13ClN2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
N-(4-chlorophenyl)-2-(3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazin-2-yl)acetamide |
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1. Qiansen Zhang, et al. Cell Res. 2022 Feb 3. doi: 10.1038/s41422-022-00616-y.
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