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YIR-819 TFA

Chemical Structure : YIR-819 TFA

CAS No.: 1883372-87-9

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YIR-819 TFA (YIR819)

Catalog No.: PC-62778Not For Human Use, Lab Use Only.

YIR-819 TFA is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YIR-819 TFA is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.6 uM against YTA48P virus with no significant cytotoxicity (CC50=33 uM).
    YIR-819  is a useful lead compound for the further development of HIV-1 entry inhibitors and could potentially be useful for co-administration with neutralizing antibodies for the treatment of HIV infection and AIDS.

    Physicochemical Properties

    M.Wt 606.044
    Formula C25H35ClF3N7O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1-(4-chlorophenyl)-N2-(1-(2-(2-guanidinoacetamido)ethyl)-1-azaspiro[5.5]undecan-4-yl)oxalamide TFA salt

    References

    1. Ohashi N, et al. ChemMedChem. 2016 Apr 19;11(8):940-6.

    2. Boonstra A, et al. Antivir Ther. 2012;17(4):657-67.

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