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YIR-821

Chemical Structure : YIR-821

CAS No.: 1883372-91-5

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YIR-821 (YIR821)

Catalog No.: PC-62901Not For Human Use, Lab Use Only.

YIR-821 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.8 uM against YTA48P virus with no significant cytotoxicity (CC50>200 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YIR-821 is a small-molecule CD4 mimic that acts as a highly potent HIV entry inhibitor with IC50 of 2.8 uM against YTA48P virus with no significant cytotoxicity (CC50>200 uM).
    YIR-821 is a useful lead compound for the further development of HIV-1 entry inhibitors and could potentially be useful for co-administration with neutralizing antibodies for the treatment of HIV infection and AIDS.

    Physicochemical Properties

    M.Wt 534.102
    Formula C26H40ClN7O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N1-(4-chlorophenyl)-N2-(1-(2-(5-guanidinopentanamido)ethyl)-1-azaspiro[5.5]undecan-4-yl)oxalamide

    References

    1. Ohashi N, et al. ChemMedChem. 2016 Apr 19;11(8):940-6.

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