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Chemical Structure : YJ9069
Catalog No.: PC-23148Not For Human Use, Lab Use Only.
YJ9069 is a selective CDK12/13 PROTAC degrader, exhibits preferential cytotoxicity in multiple cancers.
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YJ9069 is a selective CDK12/13 PROTAC degrader, exhibits preferential cytotoxicity in multiple cancers.
YJ9069 effectively inhibited phosphorylation of RNA polymerase II at serine 2 in VCaP and 22Rv1 cells.
YJ9069 effectively inhibited cell growth as measured by IncuCyte in a dose-dependent manner while having no antiproliferative effect on benign or non-neoplastic prostate cells at parallel doses.
YJ9069 suppresses tumor growth in multiple in vivo prostate cancer models.
| M.Wt | 849.95 | |
| Formula | C47H47N9O7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Chang Y, et al. Cell Rep Med. 2024 Sep 21:101752. doi: 10.1016/j.xcrm.2024.101752.
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