YJ9069 | CDK12/13 PROTAC | Probechem Biochemicals

Chemical Structure : YJ9069

YJ9069 (YJ-9069)

Catalog No.: PC-23148Not For Human Use, Lab Use Only.

YJ9069 is a selective CDK12/13 PROTAC degrader, exhibits preferential cytotoxicity in multiple cancers.

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Biological Activity

YJ9069 is a selective CDK12/13 PROTAC degrader, exhibits preferential cytotoxicity in multiple cancers.
YJ9069 effectively inhibited phosphorylation of RNA polymerase II at serine 2 in VCaP and 22Rv1 cells.
YJ9069 effectively inhibited cell growth as measured by IncuCyte in a dose-dependent manner while having no antiproliferative effect on benign or non-neoplastic prostate cells at parallel doses.
YJ9069 suppresses tumor growth in multiple in vivo prostate cancer models.

Physicochemical Properties

M.Wt	849.95
Formula	C47H47N9O7
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-[4-[4-[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]-1-piperazinyl]phenyl]-N′-(phenylmethyl)-N-[trans-4-(2-quinazolinylamino)cyclohexyl]-

References

1. Chang Y, et al. Cell Rep Med. 2024 Sep 21:101752. doi: 10.1016/j.xcrm.2024.101752.

YJ9069 (YJ-9069)

Biological Activity

Physicochemical Properties

References

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