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Chemical Structure : YKL-06-101
Catalog No.: PC-73098Not For Human Use, Lab Use Only.
YKL-06-101 is a bivalent small molecule that combines mTOR inhibition (IC50=6 nM) and degradation of CDK8 (CDK8/Cyclin C IC50=31 nM).
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YKL-06-101 is a bivalent small molecule that combines mTOR inhibition (IC50=6 nM) and degradation of CDK8 (CDK8/Cyclin C IC50=31 nM).
The bivalent degrader YKL-06-101 stops proliferation of BCR-ABL1+ (Z119, BV173) and of BCR-ABL1− cells (REH) at concentrations below 1 uM.
YKL-06-101 reduces phosphorylation of S6S240/244, as indication of mTOR inhibition.
YKL-06-101 induces cell death in human leukemic cells.
| M.Wt | 1099.134 | |
| Formula | C58H57F3N8O11 | |
| Appearance | Solid | |
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1. Ingeborg Menzl, et al. Nat Commun. 2019 Oct 18;10(1):4741.
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