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YKL-06-101

Chemical Structure : YKL-06-101

CAS No.:

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YKL-06-101

Catalog No.: PC-73098Not For Human Use, Lab Use Only.

YKL-06-101 is a bivalent small molecule that combines mTOR inhibition (IC50=6 nM) and degradation of CDK8 (CDK8/Cyclin C IC50=31 nM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YKL-06-101 is a bivalent small molecule that combines mTOR inhibition (IC50=6 nM) and degradation of CDK8 (CDK8/Cyclin C IC50=31 nM).
    The bivalent degrader YKL-06-101 stops proliferation of BCR-ABL1+ (Z119, BV173) and of BCR-ABL1− cells (REH) at concentrations below 1 uM.
    YKL-06-101 reduces phosphorylation of S6S240/244, as indication of mTOR inhibition.
    YKL-06-101 induces cell death in human leukemic cells.

    Physicochemical Properties

    M.Wt 1099.134
    Formula C58H57F3N8O11
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(2,6-dioxopiperidin-3-yl)-4-((18-(4-(4-(9-(isoquinolin-7-yl)-2-oxobenzo[h][1,6]naphthyridin-1(2H)-yl)-2-(trifluoromethyl)phenyl)piperazin-1-yl)-18-oxo-3,6,9,12,15-pentaoxaoctadecyl)amino)isoindoline-1,3-dione

    References

    1. Ingeborg Menzl, et al. Nat Commun. 2019 Oct 18;10(1):4741.

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