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YL5084

Chemical Structure : YL5084

CAS No.: 2440199-73-3

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YL5084 (YL 5084)

Catalog No.: PC-49846Not For Human Use, Lab Use Only.

YL5084 (YL 5084) is a potent, selective and covalent JNK2/3 inhibitor with IC50 of 70 nM (JNK2), displays selectivity (>30-fold) for JNK2 over JNK1.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YL5084 (YL 5084) is a potent, selective and covalent JNK2/3 inhibitor with IC50 of 70 nM (JNK2), displays selectivity (>30-fold) for JNK2 over JNK1.
    YL5084 forms a covalent bond with Cys116 of JNK2, exhibits a 20-fold higher Kinact/KI compared to that of JNK1, and engages JNK2 in cells.
    YL5084 exhibited JNK2-independent antiproliferative effects in multiple myeloma cells.

    Physicochemical Properties

    M.Wt 600.73
    Formula C35H36N8O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-4-(dimethylamino)-N-(4-((3S,4S)-3-methyl-4-((4-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)pyrimidin-2-yl)amino)pyrrolidine-1-carbonyl)phenyl)but-2-enamide

    References

    1. Wenchao Lu, et al. J Med Chem. 2023 Mar 9;66(5):3356-3371. 

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