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YLC2-155

Chemical Structure : YLC2-155

CAS No.: 1354742-60-1

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YLC2-155 (YLC 2-155;YLC2155)

Catalog No.: PC-61948Not For Human Use, Lab Use Only.

YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    YLC2-155 is a novel potent HIV-1 reverse transcriptase (RT) inhibitor that inhibits both polymerase (IC50=2.6 uM) and RNase H function (IC50=0.65 uM) of RT.
    YLC2-155 binds at the RNase H (RNH)-active site in multiple conformations.
    YLC2-155 demonstrates inhibition of fully infectious HIV-1 (strain NL4-3) with EC50 of 6.7 uM in cell-based assays.

    Physicochemical Properties

    M.Wt 243.22
    Formula C13H9NO4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    7-(furan-2-yl)-2-hydroxyisoquinoline-1,3(2H,4H)-dione

    References

    1. Kirby KA, et al. Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e01351-17.

    2. Kirby KA, et al. Antimicrob Agents Chemother. 2012 Apr;56(4):2048-61.

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