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Chemical Structure : YM-155
CAS No.: 781661-94-7
Catalog No.: PC-42439Not For Human Use, Lab Use Only.
Sepantronium bromide (YM-155) is a potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM, targets RIPK2 kinase activity.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 250 mg | Get quote |
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Sepantronium bromide (YM-155) is a potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM, targets RIPK2 kinase activity.
YM-155 does not significantly inhibit SV40 promoter activity (>30 uM).
YM-155 suppresses expression of survivin and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nM, without effect on IAP- or Bcl-2-related proteins.
YM-155 induces massive tumor regression in PC-3 tumor mice model (3-10 mg/kg).
| M.Wt | 443.2939 | |
| Formula | C20H19BrN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10.66 mg/mL |
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| Chemical Name/SMILES |
1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide (1:1) |
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1. Nakahara T, et al. Cancer Res. 2007 Sep 1;67(17):8014-21.
2. Iwasa T, et al. Clin Cancer Res. 2008 Oct 15;14(20):6496-504.
3. Satoh T, et al. Clin Cancer Res. 2009 Jun 1;15(11):3872-80.
4. Iwasa T, et al. Br J Cancer. 2010 Jun 29;103(1):36-42.
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