YM-155 hydrochloride is a potent, specific survivin inhibitor that inhibits survivin promoter activity with IC50 of 0.54 nM.
YM-155 does not significantly inhibit SV40 promoter activity (>30 uM).
YM-155 suppresses expression of survivin and induces apoptosis in PC-3 and PPC-1 human HRPC cell lines at 10 nM, without effect on IAP- or Bcl-2-related proteins.
YM-155 induces massive tumor regression in PC-3 tumor mice model (3-10 mg/kg).
