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Chemical Structure : YM26734
Catalog No.: PC-38483Not For Human Use, Lab Use Only.
YM-26734 is a potent, selective and competitive inhibitor of extracellular group II phospholipase A2 (sPLA2) with IC50 of 85 nM (rabbit platelet-derived group II), >70-fold selectivity over group I PLA2.
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YM-26734 is a potent, selective and competitive inhibitor of extracellular group II phospholipase A2 (sPLA2) with IC50 of 85 nM (rabbit platelet-derived group II), >70-fold selectivity over group I PLA2.
YM-26734 did not reduce the activity of intracellular PLA2 prepared from mouse macrophages, which preferentially hydrolyzed arachidonoyl phospholipids at concentrations up to 50 uM.
YM-26734 also showed no effect against either sheep seminal vesicle cyclo-oxygenase or rat leukocyte 5-lipoxygenase.
YM-26734 is a competitive inhibitor of group II PLA2 derived from rabbit platelets with Ki of 48 nM.
YM-26734 inhibited 12-O-tetradecanoylphorbol-13-acetate (TPA, 1 mg/ear)-induced ear oedema in a dose-dependent manner, with ED50 values of 45 mg/ear and 11 mg/kg, i.v.
| M.Wt | 730.983 | |
| Formula | C45H62O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Miyake A, et al. Br J Pharmacol. 1993 Sep;110(1):447-53.
2. Miyake A, et al. Eur J Pharmacol. 1994 Feb 21;253(1-2):155-61.
3. Rodríguez Diez G, et al. Exp Eye Res. 2013 Aug;113:172-81.
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