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Chemical Structure : YM 758
Catalog No.: PC-60990Not For Human Use, Lab Use Only.
A novel potent "funny" If current channel (If channel) inhibitor that inhibits rOct1- and hOCT1-mediated [3H]MPP uptake with IC50 of 23.8 and 40.5 uM, respectively.
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A novel potent "funny" If current channel (If channel) inhibitor that inhibits rOct1- and hOCT1-mediated [3H]MPP uptake with IC50 of 23.8 and 40.5 uM, respectively; inhibits OATP1B1-mediated [3H]E217βG uptake in HEK293 cells with IC50 of 13.0 uM and has no inhibitory effect on OATP1B3-mediated [3H]E217βG uptake; selectively lowers the heart rate and decreases oxygen consumption by heart muscle.
| M.Wt | 469.557 | |
| Formula | C26H32FN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Umehara K, et al. Drug Metab Dispos. 2008 Jun;36(6):1030-8.
2. Umehara KI, et al. Xenobiotica. 2008 May;38(5):527-39.
3. Umehara KI, et al. Eur J Drug Metab Pharmacokinet. 2008 Oct-Dec;33(4):211-23.
4. Nakada N. Drugs R D. 2016 Jun;16(2):205-16.
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