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Chemical Structure : YM976
CAS No.: 191219-80-4
Catalog No.: PC-22040Not For Human Use, Lab Use Only.
YM976 is a potent, selective phosphodiesterase type 4 (PDE4) inhibitor with IC50 of 2.2 nM against PDE4 purified from human peripheral leukocytes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 MG | $138 | In stock | |
| 50 MG | $218 | In stock | |
| 100 MG | Get quote |
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YM976 is a potent, selective phosphodiesterase type 4 (PDE4) inhibitor with IC50 of 2.2 nM against PDE4 purified from human peripheral leukocytes.
YM976 has no effects on the other PDE isozymes, PDE1, -2, -3, and -5.
YM976 potentiates prostaglandin E(2)-induced cAMP accumulation in a human mononuclear cell line, U937, and YM976 inhibits TNF-alpha production from human peripheral blood mononuclear cells stimulated by lipopolysaccharide.
YM976 inhibits the cell infiltration into the pleural cavity with oral ED(30) values of 9.1 mg/kg in rat carrageenan-induced pleurisy models.
YM976 dose dependently reduces carrageenan-induced leukocyte infiltration at the doses of 1, 3, and 10 mg/kg, p.o.
| M.Wt | 313.79 | |
| Formula | C17H16ClN3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one |
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1. Aoki M, et al. J Pharmacol Exp Ther. 2000 Oct;295(1):255-60.
2. Aoki M, et al. J Pharmacol Exp Ther. 2000 Dec;295(3):1149-55.
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