Chemical Structure : YN1548
CAS No.:
2643967-34-2
YN1548
(YN-1548)
Catalog No.: PC-25559Not For Human Use, Lab Use Only.
YN1548 is a potent, highly selective agonist of human glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 4.59, 24.28, and 2.20 nM in CHO cells expressing low, mid, and high human GLP-1 receptor levels in a dose-dependent manner, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
YN1548 is a potent, highly selective agonist of human glucagon-like peptide-1 receptor (GLP-1R) with EC50 of 4.59, 24.28, and 2.20 nM in CHO cells expressing low, mid, and high human GLP-1 receptor levels in a dose-dependent manner, respectively.
YN1548 induces β-arrestin 2 translocation with an Emax of 40.0 %, demonstrates Emax comparable to GLP-1 (7–36) amide.
YN1548 is highly selective for GLP-1 receptor among the glucagon receptor family, does not activate cAMP response in CHO cells expressing GLP-2 receptor, GIP receptor, or glucagon receptor
YN1548 binding to cynomolgus monkey GLP-1 receptor expressed in CHO cells enhanced the intracellular cAMP concentration at an EC50 of 59.91 nM and an Emax of 101.5 %.
Oral administration of YN1548 reduced blood glucose levels and enhanced insulin secretion in a concentration-dependent manner in diabetic monkeys.
Physicochemical Properties
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M.Wt
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571.61
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Formula
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C30H30FN7O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(((S)-4-(6-((4-cyano-2-fluorobenzyl)oxy)pyrazin-2-yl)-2-methylpiperazin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-benzo[d]imidazole-6-carboxylic acid
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References
1. Je IG, et al. YN1548: A novel small-molecule agonist of human glucagon-like peptide-1 receptor for the treatment of type 2 diabetes mellitus and obesity. Eur J Pharmacol. 2025 Sep 11;1006:178143.
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