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YNW-1

Chemical Structure : YNW-1

CAS No.: 3097630-45-7

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YNW-1 (YNW1)

Catalog No.: PC-28722Not For Human Use, Lab Use Only.

YNW-1 is a bident, covalent EGFR inhibitor with IC50 of 15.82 nM, 18.97 nM and 62.45 nM for EGFR L858R Ba/F3, EGFR L858R/C775S Ba/F3, and EGFR L858R/C797S Ba/F3 cells respectvely, covalently targets both cysteines 775 and 797 simultaneously.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YNW-1 is a bident, covalent EGFR inhibitor with IC50 of 15.82 nM, 18.97 nM and 62.45 nM for EGFR L858R Ba/F3, EGFR L858R/C775S Ba/F3, and EGFR L858R/C797S Ba/F3 cells respectvely, covalently targets both cysteines 775 and 797 simultaneously.
(50-100 nM) inhibits downstream signaling including p-EGFR/ERK and AKT.
YNW-1 has broad activity against EGFR mutants and delayed acquired mutations.

Physicochemical Properties

M.Wt 703.85
Formula C39H45N9O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-6-(4-acryloyl-5-methyl-3,4-dihydroquinoxalin-1(2H)-yl)-8-(1-acryloylpiperidin-3-yl)-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one

References

1. Li Z, et al. ACS Cent Sci. 2026 Sep 29;12(10):1647-1658.

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