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Chemical Structure : YPD-29B
Catalog No.: PC-20282Not For Human Use, Lab Use Only.
YPD-29B is a potent, specific programmed cell death ligand 1 (PD-L1) inhibitor, effectively blocks the binding of PD-1 and PD-L1 with IC50 of 0.08 pM in HTRF protein-protein interaction assays.
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YPD-29B is a potent, specific programmed cell death ligand 1 (PD-L1) inhibitor, effectively blocks the binding of PD-1 and PD-L1 with IC50 of 0.08 pM in HTRF protein-protein interaction assays.
YPD-29B is the active metabolite of YPD-30 (Cat# PC-20281).
YPD-29B did not inhibit any other immune checkpoints, including hCD28/B7-1, hCD28/B7-2, hCTLA4/B7-1, and hCTLA4/B7-2 and LAG3/MHCII.
YPD-29B also suppressed the interaction of hPD-L1/hB7-1 with an IC50 of 0.3 nM.
YPD-29B binds to hPD-L1 with SPR KD of 0.02 nM, but not hPD-1. activates T lymphocytes and overcomes immunity tolerance by disrupting the hPD-1/PD-L1 interaction.
YPD-29B induces internalization and degradation of PD-L1.
| M.Wt | 597.89 | |
| Formula | C29H26BrClN2O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Fangfang Lai, et al. Acta Pharm Sin B. 2022 Jun;12(6):2845-2858.
2. Wang Y, et al. Pharmaceutics. 2021 Apr 21;13(5):598.
3. Patent: CN109153670.
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