Catalog No.: PC-20282Not For Human Use, Lab Use Only.
YPD-29B is a potent, specific programmed cell death ligand 1 (PD-L1) inhibitor, effectively blocks the binding of PD-1 and PD-L1 with IC50 of 0.08 pM in HTRF protein-protein interaction assays.
YPD-29B is a potent, specific programmed cell death ligand 1 (PD-L1) inhibitor, effectively blocks the binding of PD-1 and PD-L1 with IC50 of 0.08 pM in HTRF protein-protein interaction assays.
YPD-29B is the active metabolite of YPD-30 (Cat# PC-20281).
YPD-29B did not inhibit any other immune checkpoints, including hCD28/B7-1, hCD28/B7-2, hCTLA4/B7-1, and hCTLA4/B7-2 and LAG3/MHCII.
YPD-29B also suppressed the interaction of hPD-L1/hB7-1 with an IC50 of 0.3 nM.
YPD-29B binds to hPD-L1 with SPR KD of 0.02 nM, but not hPD-1. activates T lymphocytes and overcomes immunity tolerance by disrupting the hPD-1/PD-L1 interaction.
YPD-29B induces internalization and degradation of PD-L1.
